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Nerve Regeneration by Wild Mushroom Hericium erinaceus

By Dr. Markho Rafael


Out of the kitchen, into the pharmacy, the gourmet mushroom Lion's Mane (Hericium erinaceus) with its unique flavor resembling lobster or shrimp appears to also possess likewise unique medicinal properties. It has been found to stimulate nerve and myelin regeneration, which may be beneficial in many neurological conditions. World renowned medicinal mushroom expert Paul Stamets suggests its potential application in conditions such as Alzheimer's, dementia, multiple sclerosis and muscular dystrophy. (134)

In the wild, Lion's Mane Mushroom (Hericium erinaceus) grows on hardwood trees, especially oak, sycamore, maple, walnut and beech. It can be found throughout the temperate areas of the world, from North America and Europe to Japan and China.

The active compounds that have received the most attention for their nerve regenerating properties are named erinacines, a series of low molecular weight molecules that are able to pass through the blood brain barrier - an essential attribute for any medicinal compound expected to be able to effect healing on myelin or nerve tissue. (152, 153, 154)

Two Japanese patents exist relating to Hericium erinaceus extracts; one from the 1990's for an extraction process of these compounds yielding an extract known as "Nerve Growth Stimulant Factor." (150, 151) A more recent one from 2004 is for a water extract of Hericium erinaceus, also used for its nerve regenerating properties. (155)

In addition to its effect on nerve regeneration, Traditional Chinese Medicine (TCM) also prescribes Hericium erinaceus extract for stomach and digestive conditions, as well as cancers of the digestive tract and related organs.

Modern science has provided some support for this traditional use of Hericium erinaceus extract. One study conducted in 1985 reported positive results for treating atrophic gastritis. Another, published in 1995, presented findings that Hericium erinaceus helped extend the average life expectancy for patients with hepatoma. (156)

Note: The statements on this page have not been evaluated by the Food and Drug Administration. This article is not intended to diagnose, treat, cure or prevent any disease. Never use any medicinal mushroom or herb without prior approval by medical doctor.

Credit to Paul Stamets for research and source material.




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