A liposome, an artificial vesicle comprises a double layer of fatty acids. It may be used as tools utilized to administer nutrients and pharmaceutical drugs to your body systems. They may be made by disrupting some biological membranes which may somehow involve sonication.
Liposomes are typically composed of natural phospholipids. Moreover, they may as well be made of combined lipid chains bearing quite a high level of surfactant properties. These lipid chains can include egg phosphatidylethanolamine. Their design may take the form of surface ligands that are used for attaching the tissues that are unhealthy.
There are different types of these artificial lipid rich vesicles. The main types of liposomes include multilamellar vesicle which is abbreviated as MLV, a small unilamellar vesicle which is shortened as SUV, a large unilamellar vesicle whose abbreviation is LUV, and finally the cochleate vesicle.
These products can easily be confused with micelles and reverse micelles. This might occur because they are nearly similar in structure. Their only difference is that liposomes have a double layer of lipids whereas micelles as well as reverse micelles are made of single layers of lipids.
The membranes of these structures are usually composed of phospholipids, which refer to the molecules which have head group as well as a tail group. Their heads are usually attracted to water. However, the tail is usually made of a long chain of hydrocarbon hence is usually repelled by water.
Their hydrophilic heads comprise the outermost layers whereas their hydrophobic tails comprise the internal layers. This is so since their heads are pulled by water molecules while the tails are resisted by water particles. Conversely, in each cell, the layer of heads constantly faces outside, and is attracted to the charged water environment. The next layer of the heads faces inside the cell, and gets pulled to the water molecules found in the cell. Nonetheless, hydrophobic tails of its outermost layer face similar tails of the internal layers, thus forming a dual layer design.
Liposomes were designated by a British hematologist known as Dr. Alec Bangham in 1961 in the institution of Babraham at Cambridge. It was later published in the year 1964. They were clearly found to take after plasmalemma. This was evidenced by pictures that were formed by a microscope that Bangham had used.
They encapsulate an aqueous solution using a hydrophobic membrane. Chemicals which are insoluble in water easily pass across their membranes whereas the ones soluble in water do not. Nonetheless, dissolved hydrophilic particles are able to go through hydrophilic heads. As a result, it may be utilized in releasing hydrophobic and hydrophilic particles. It releases its constituents by adhering to other organelles with similar bilayer walls for instance cell membranes.
These vesicles are used in both drug and gene delivery application. The drugs and the DNA to be delivered are usually made to contain the pH that is suitable for the functions of the liposome. Its use in the transformation of DNA is called lipofection. Furthermore, it can also be used to deliver dyes to textiles, enzymes and dietary supplements to foods, pesticides to plants and also cosmetics to skin.
Liposomes are typically composed of natural phospholipids. Moreover, they may as well be made of combined lipid chains bearing quite a high level of surfactant properties. These lipid chains can include egg phosphatidylethanolamine. Their design may take the form of surface ligands that are used for attaching the tissues that are unhealthy.
There are different types of these artificial lipid rich vesicles. The main types of liposomes include multilamellar vesicle which is abbreviated as MLV, a small unilamellar vesicle which is shortened as SUV, a large unilamellar vesicle whose abbreviation is LUV, and finally the cochleate vesicle.
These products can easily be confused with micelles and reverse micelles. This might occur because they are nearly similar in structure. Their only difference is that liposomes have a double layer of lipids whereas micelles as well as reverse micelles are made of single layers of lipids.
The membranes of these structures are usually composed of phospholipids, which refer to the molecules which have head group as well as a tail group. Their heads are usually attracted to water. However, the tail is usually made of a long chain of hydrocarbon hence is usually repelled by water.
Their hydrophilic heads comprise the outermost layers whereas their hydrophobic tails comprise the internal layers. This is so since their heads are pulled by water molecules while the tails are resisted by water particles. Conversely, in each cell, the layer of heads constantly faces outside, and is attracted to the charged water environment. The next layer of the heads faces inside the cell, and gets pulled to the water molecules found in the cell. Nonetheless, hydrophobic tails of its outermost layer face similar tails of the internal layers, thus forming a dual layer design.
Liposomes were designated by a British hematologist known as Dr. Alec Bangham in 1961 in the institution of Babraham at Cambridge. It was later published in the year 1964. They were clearly found to take after plasmalemma. This was evidenced by pictures that were formed by a microscope that Bangham had used.
They encapsulate an aqueous solution using a hydrophobic membrane. Chemicals which are insoluble in water easily pass across their membranes whereas the ones soluble in water do not. Nonetheless, dissolved hydrophilic particles are able to go through hydrophilic heads. As a result, it may be utilized in releasing hydrophobic and hydrophilic particles. It releases its constituents by adhering to other organelles with similar bilayer walls for instance cell membranes.
These vesicles are used in both drug and gene delivery application. The drugs and the DNA to be delivered are usually made to contain the pH that is suitable for the functions of the liposome. Its use in the transformation of DNA is called lipofection. Furthermore, it can also be used to deliver dyes to textiles, enzymes and dietary supplements to foods, pesticides to plants and also cosmetics to skin.
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